2001 Manchester
College Football Schedule
| Date | Opponent | Location | Time (local) | Result | Record | |
| Sept. 8 | Sat. | Wabash | Crawfordsville, In | 1:00 p.m. | L 45-21 | 0-1 |
| Sept. 15 | Sat. | Olivet | HOME | 7:00 p.m. | W 29-15 | 1-1 |
| Sept. 22 | Sat. | Earlham | Richmond, In | 1:00 p.m. | L 41-14 | 1-2 |
| Sept. 29 | Sat. | Franklin | HOME | 1:30 p.m. | L 45-36 | 1-3, 0-1 |
| Oct. 6 | Sat. | Thomas More | HOME | 1:30 p.m. | L 55-0 | 1-4 |
| Oct. 13 | Sat. | Defiance | Defiance, Ohio | 1:30 p.m. *EST* | L 38-20 | 1-5, 0-2 |
| Oct. 20 | Sat. | Bluffton | HOMECOMING | 1:30 p.m. | L 38-3 | 1-6, 0-3 |
| Oct. 27 | Sat. | Mount St. Joseph | Cincinnati, Ohio | 1:30 p.m. *EST* | W 16-10 | 2-6, 1-3 |
| Nov. 3 | Sat. | Hanover | HOME | 1:30 p.m. | L 29-16 | 2-7, 1-4 |