1999 Manchester College Football Schedule
| Date | Opponent | Location | Time (local) | Result | Record | |
| Sept. | 11 | Waynesburg | Away | 12:00 p.m. | W 39-37 | 1-0 |
| 18 | Olivet | HOME | 1:30 p.m. | W 37-15 | 2-0 | |
| 25 | Albion | Away | 12:30 p.m. | L 49-23 | 2-1 | |
| Oct. | 2 | Franklin* | Away | 1:30 p.m. | L 22-6 | 2-2 (0-1) |
| 9 | Hanover* | HOME | 1:30 p.m. | L 45-14 | 2-3 (0-2) | |
| 16 | Wabash* | HOME | 1:30 p.m. | L 23-3 | 2-4 (0-3) | |
| 23 | Bluffton* | Away | 12:30 p.m. | L 26-10 | 2-5 (0-4) | |
| 30 | Wilmington | Away | 12:30 p.m. | L 39-0 | 2-6 (0-5) | |
| Nov. | 6 | Mt. St. Joseph | HOME | 1:30 p.m. | L 28-21 OT | 2-7 (0-6) |
| 13 | Anderson | HOME | 1:30 p.m. | L 27-25 | 2-8 (0-7) |