Pharmacy, Natural & Health Sciences

MS in Pharmacogenomics On-Campus Program Course Sequence

 

Semester 1 – Summer

Course name

Course description

Credit hours

PGX 501 Introduction to Pharmacogenomics

Prerequisite: none

A presentation of the evolution of pharmacogenetics/pharmacogenomics, the human genome and modern applications of DNA information related to drugs.  There will also be focused attention to necessary calculations for research and an introduction to pharmacokinetics.

2

PGX 505 Pharmacology
       

Prerequisite: none

Discusses the cellular and molecular mechanisms of drug action, studied within the disciplines of neuropharmacology and cardiovascular pharmacology, endocrine pharmacology, antimicrobials, and cancer pharmacology.  Included are lectures on basic physiology that underlie the mechanisms of important pharmacological agents.  Special topics include drug discovery, new uses for established drugs, and pharmacogenetic/pharmacogenomic effects. 

4

PGX 521 Human Genetics (Online course)
       

Prerequisite: none

Discusses how genes influence human traits, diseases, and behaviors, including how non-genetic factors interact with genetic factors to produce observable phenotypes. Human inheritance patterns, genome organization, linkage, and medical applications of genetics in the diagnosis, treatment, and prevention of disease will be explored.  There will also be an introduction to molecular biology.

4

PGX 514 Analytical Technology I
       

Prerequisite: none

On-Campus Lab: Analytical technique approaches in molecular biology, such as DNA, manipulation and mutation analysis, protein assays, and quantitative analysis of gene expression, among other techniques.

1

PGX 515 Research Responsibility and Ethics

Prerequisite: none

Discusses ethics of scientific research involving humans.  Bioethics and how it is applied to design and conduct of human drug research.  Ethical issues involved with personal genetic information will be emphasized.  

1

Semester 2 – Fall

Course name

Course description

Credit hours

PGX 526 Applied Pharmacogenomics 1

Prerequisite: PGX 501 (grade of "C" or better or permission)

Discusses single nucleotide polymorphisms and other genetic variations and their potential impact on clinical medicine and related clinical outcomes.  The translation of genetic variations to drug selection, dosing regimens, adverse effects, and regimen optimization will be discussed.

3

PGX 531 Bioinformatics (Online course)
       

Prerequisite: none

7-Week Online Course: Introduction and exploration of the computational and informational aspects of genomics and proteomics. Includes aspects of sequence similarity analysis, sequence similarity searches, pair-wise analysis, phylogenic trees (and relevance to human genomics), allelic variation analysis, user interface in health care management, population genetics, genomics data results analysis, data quality, and predictions and confirmations of genomics-based altered drug responses. 

4

PGX 512 Advanced Pharmacokinetics
       

Prerequisite: PGX 501 (grade of "C" or better or permission)

Discusses the mathematical and conceptual study of the time course of drug absorption, distribution, metabolism, and excretion.

2

PGX 524 Analytical Technology II
       

Prerequisite: PGX 514 (grade of "C" or better or permission)

On-Campus Lab: Continuation of Analytical Technology I

2

Semester 3 – Spring

Course name

Course description

Credit hours

PGX 536 Applied Pharmacogenomics 2
       

Prerequisites: PGX 501 and PGX 526 (grade of "C" or better or permission)

A continuation of Applied Pharmacogenomics and will continue to focus on single nucleotide polymorphisms and other genetic variation and their potential impact on clinical medicine and related clinical outcomes.  The translation of genetic variations to drug selection, dosing regimens, adverse effects, and regimen optimization will be discussed.

3

PGX 511 Advanced Molecular Biology
       

Prerequisite: PGX 521 (grade of "C" or better or permission)

Concepts will be related to analytical methodology. Current approaches to DNA manipulation and mutation analysis, protein assays, quantitative analysis of gene expression, sequencing, immunostaining, microscopy, and image analysis will be discussed.

3

PGX 533 Data Analysis/Biostatistics
(Online course)

Prerequisite: none

7-Week Online Course: Discusses the use of statistical methods to process public health and genetic data.  An emphasis on interpretation and concepts in areas such as population genetics, genome-wide association studies and systems biology will be undertaken.

3

PGX 534 Analytical Technology III

Prerequisites: PGX 514 and PGX 524 (grade of "C" or better or permission)

On-Campus Lab: Continuation of Analytical Technology I

2

Total Credit Hours

34