Pharmacy, Natural & Health Sciences

Pharmacogenomics - Faculty Profiles

Venkatareddy Nadithe

Venkatareddy Nadithe, Ph.D.

Assistant Professor of Pharmaceutical Sciences (Pharmaceutics)
vnadithe@manchester.edu

 

Dr. Nadithe joined the Manchester University College of Pharmacy, Natural and Health Sciences in July 2014 and he is responsible for conceptualizing, developing and teaching courses in Pharmaceutics. Dr. Nadithe received his undergraduate degree in Pharmacy from Kakatiya University, India with a focus on Pharmaceutics and Biopharmaceutics. He completed Master of Science degree in Pharmaceutical Sciences from University of Alberta, Canada before entering the prestigious PhD program in Pharmaceutics and Pharmaceutical Chemistry at the University of Utah, Salt Lake City. Prior to joining as full-time Faculty, Dr. Nadithe completed his post-doctoral research fellowship at Wayne State University working on polymeric delivery systems for siRNA. Dr. Nadithe is an active member of American Association of Pharmaceutical Scientists (AAPS) and Controlled Release Society (CRS).

CERTIFICATION

Foreign Pharmacy Graduate Certification - 2016, National Association of Boards of Pharmacy.

 

COURSES taught at Manchester University

  • Pharmaceutics
  • Pharmaceutical Calculations
  • Pharmaceutical Compounding
  • Basic Pharmacokinetics

RESEARCH INTERESTS

My primary research interests focus on 3 key areas of Pharmaceutics and Drug delivery.

  • Design hybrid biomaterials (natural and synthetic lipids and polymeric materials): Synthesis and evaluation of new materials for formulation and drug delivery of therapeutic pharmaceutical drug molecules. This research incorporates a range of interdisciplinary approaches and characterizations at molecular and nano-scale level.

  • Targeted drug delivery strategies: Current active targeting approaches still have significant amount of drugs delivered by non-specific mechanism and thus associated unwanted effects. Projects will involve specific multifunctional drug delivery designs using small molecular weight chemically synthesized pharmaceutical drugs and biologics.

  • Formulation strategies for newer generation of biologics: Research projects will focus on providing solutions to critical formulation problems for biological drugs (complex peptides/siRNA & Gene Editing).

SELECT REPRESENTATIVE PUBLICATIONS

  • D. Ha, N. Yang, V. Nadithe. “Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges”. Acta Pharmaceutica Sinica B, 6(4):287-96, 2016.

  • V. Nadithe, R. Liu, NH. Kim, KS. Masters, SH. Gellman, OM. Merkel. “Rational screening of Nylon-3 polymers, a new class of cationic amphiphiles for siRNA delivery”. Molecular Pharmaceutics, 12(2):362-374, 2015.

  • V. Nadithe, D. Mishra, YH. Bae. “Poly(ethylene glycol) cross-linked hemoglobin with antioxidant enzymes protects pancreatic islets from hypoxia and free radical stress and extends the islet functionality”. Biotechnology and Bioengineering. 109(9):2392-2401, 2012.

  • V. Nadithe, M. Rahamatalla, WH. Finaly, JR. Mercer, and J. Samuel. “Evaluation of nose-only aerosol inhalation chamber and comparison of experimental results with mathematical simulation of aerosol deposition in mice lungs”. Journal of Pharmaceutical Sciences. 92(5):1066-1076, 2003.