Pharmacy, Natural & Health Sciences

Pharmacogenomics

On-campus Program

40 Credits


Semester 1 – Summer

Course name

Course description

Credit hours

Introduction to Pharmacogenomics
(PGx 501)

A presentation of the evolution of pharmacogenetics/pharmacogenomics, the human genome and modern applications of DNA information related to drugs.  There will also be focused attention to necessary calculations for research and an introduction to pharmacokinetics.

2

Pharmacology
(PGx 510/520)

Discusses the cellular and molecular mechanisms of drug action, studied within the disciplines of neuropharmacology and cardiovascular pharmacology, endocrine pharmacology, antimicrobials, and cancer pharmacology.  Included are lectures on basic physiology that underlie the mechanisms of important pharmacological agents.  Special topics include drug discovery, new uses for established drugs, and pharmacogenetic/pharmacogenomic effects. 

4

Human Genetics
(PGx 521)

Discusses how genes influence human traits, diseases, and behaviors, including how non-genetic factors interact with genetic factors to produce observable phenotypes. Human inheritance patterns, genome organization, linkage, and medical applications of genetics in the diagnosis, treatment, and prevention of disease will be explored.  There will also be an introduction to molecular biology.

4

Patient Genome Evaluation I
(PGx 519)

Longitudinal project, investigating the genome of a patient.

2

Analytical Technology I
(PGx 514)

Analytical technique approaches in molecular biology, such as DNA, manipulation and mutation analysis, protein assays, and quantitative analysis of gene expression, among other techniques.

1

Research Responsibility and Ethics
(PGx 515)

Discusses ethics of scientific research involving humans.  Bioethics and how it is applied to design and conduct of human drug research.  Ethical issues involved with personal genetic information will be emphasized.  

1

Semester 2 – Fall

Course name

Course description

Credit hours

Applied Pharmacogenomics 1
(PGx 526)

Discusses single nucleotide polymorphisms and other genetic variations and their potential impact on clinical medicine and related clinical outcomes.  The translation of genetic variations to drug selection, dosing regimens, adverse effects, and regimen optimization will be discussed.

3

Bioinformatics
(PGx 531)

Introduction and exploration of the computational and informational aspects of genomics and proteomics. Includes aspects of sequence similarity analysis, sequence similarity searches, pair-wise analysis, phylogenic trees (and relevance to human genomics), allelic variation analysis, user interface in health care management, population genetics, genomics data results analysis, data quality, and predictions and confirmations of genomics-based altered drug responses. 

4

Advanced Pharmacokinetics
(PGx 512)

Discusses the mathematical and conceptual study of the time course of drug absorption, distribution, metabolism, and excretion.

2

Analytical Technology II
(PGx 524)

Continuation of Analytical Technology I

2

Patient Genome Evaluation  II
(PGx 529)

Continuation of Patient Genome Evaluation I, cumulating in a student presentations

2

Semester 3 – Spring

Course name

Course description

Credit hours

Applied Pharmacogenomics 2
(PGx 536)

A continuation of Applied Pharmacogenomics and will continue to focus on single nucleotide polymorphisms and other genetic variation and their potential impact on clinical medicine and related clinical outcomes.  The translation of genetic variations to drug selection, dosing regimens, adverse effects, and regimen optimization will be discussed.

3

Advanced Molecular Biology
(PGx 511)

Concepts will be related to analytical methodology. Current approaches to DNA manipulation and mutation analysis, protein assays, quantitative analysis of gene expression, sequencing, immunostaining, microscopy, and image analysis will be discussed.

3

Data Analysis/Biostatistics
(PGx 533)

Discusses the use of statistical methods to process public health and genetic data.  An emphasis on interpretation and concepts in areas such as population genetics, genome-wide association studies and systems biology will be undertaken.

3

Analytical Technology III
(PGx 534)

Onsite Training – Continuation of Analytical Technology I

2

Patient Genome Evaluation  III
(PGx 539)

Continuation of Patient Genome Evaluation I, cumulating in a student presentations

2

Total Credit Hours

40