Type of pharmacogene: Pharmacokinetic

CYP2D6 codes for the drug-metabolizing enzyme CYP2D6. This enzyme is responsible for metabolizing approximately twelve percent (19%) of medications. Variants of this pharmacogene may affect drug metabolism of substrate drugs.

Pharmacogene Variant of the Week (PVOW 1_11_2018): CYP2D6*2

Reference single nucleotide polymorphism number: rs16947; rs1135840

DNA base changes: c.2850C>T; c.4180G>C

Pharmacogene function as compared to normal function: Normal

Pharmacogene product: CYP2C9 drug metabolizing enzyme

Pharmacogene product activity as compared to normal activity: Normal

General Conceptual Pharmacogene Variant Information

CYP2D6*2 Imparts:

Normal drug exposure

- Normal maximum concentration

- Normal area under the curve (AUC)

- Normal half-life

Note: For a prodrug, the normal amount of active drug will be formed.

The reader is directed to https://www.pharmgkb.org/haplotype/PA165816577