PGX 501 Introduction to Pharmacogenomics - 2 hours
A presentation of the evolution of pharmacogenetics/pharmacogenomics, the human genome and modern applications of DNA information related to drugs.
PGX 510 Pharmacology I - 1 hour
Discusses the cellular and molecular mechanisms of drug action, studied within the disciplines of neuropharmacology and cardiovascular pharmacology. Included are lectures on basic neurobiology and cardiology that underlie the mechanisms of important pharmacological agents. Special topics include drug discovery, new uses for established drugs, and pharmacogenetic/pharmacogenomic effects.
PGX 511 Molecular Biology - 3 hours
Introduces the fundamental theories and molecular pathways of information transfer in the cell and explores the current techniques used to understand them. Concepts will be related to analytical methodology. Current approaches to DNA manipulation and mutation analysis, protein assays, quantitative analysis of gene expression, sequencing, immunostaining, microscopy, and image analysis will be discussed.
PGX 512 Pharmacokinetics - 2 hours
Discusses the mathematical and conceptual study of the time course of drug absorption, distribution, metabolism, and excretion.
PGX 514 Analytical Technology I - 1 hour
(Laboratory) Introduces analytical technique approaches in molecular biology, such as DNA manipulation and mutation analysis, protein assays, and quantitative analysis of gene expression, among other techniques.
PGX 515 Research Responsibility and Ethics - 1 hour
The course is a guided journey through ethics of scientific research and medical practice involving humans and animals and offers students a scaffolding for resolving potential ethical dilemmas that are inherent to pharmacogenomics. Specifically, we cover models of bioethical decision making and how they may apply to the design and conduct of human drug research and pharmacogenomic clinical practice. Ethical issues involved with personal genetic information will be emphasized.
PGX 519 Patient Genome Evaluation I - 2 hours
Personal Genome Evaluation I is the first in a set of three courses throughout the MS in Pharmacogenomics curriculum which serve as an opportunity for students to apply concepts mastered in parallel courses in each semester applied to a specific, unique patient that the student will follow throughout his or her entire programmatic work.
Students will be expected to demonstrate mastery of pharmacogenomic concepts through written reports and analysis of their assigned patient’s genome and auxiliary patient information.
Review of student work will occur at the midpoint and conclusion of each semester. Successful completion of the course includes complete, satisfactory evaluation and reporting of all assigned aspects of their patient during that semester.
PGX 520 Pharmacology II - 3 hours
Discusses the cellular and molecular mechanisms of drug action within the disciplines of endocrine pharmacology, antimicrobials, and cancer pharmacology. The endocrine subject matter will include pituitary hormones, thyroid diseases, diabetes, steroids and reproductive hormones. For the antimicrobial and cancer pharmacology subject matter, the didactic lectures will focus on drug classes and mechanisms of action.
PGX 521 Human Genetics - 4 hours
Discusses how genes influence human traits, diseases, and behaviors, including how non-genetic factors interact with genetic factors to produce observable phenotypes. Human inheritance patterns, genome organization, linkage, and medical applications of genetics in the diagnosis, treatment, and prevention of disease will be explored.
PGX 524 Analytical Technology II - 2 hours
(Laboratory) A continuation of analytical techniques related to DNA collection, preparation, analysis, here focusing on DNA amplification and sequencing, as well as genotyping using advanced instrumentation.
PGX 526 Applied Pharmacogenomics I - 3 hours
Discusses single nucleotide polymorphisms and other genetic variations and their potential impact on clinical medicine and related clinical outcomes. The translation of genetic variations to drug selection, dosing regimens, adverse effects, and regimen optimization will be discussed.
PGX 529 Patient Genome Evaluation II - 2 hours
(Laboratory) Overarching project involving concepts from each course applied to an individual’s genetic information.
PGX 531 Bioinformatics - 4 hours
Introduction and exploration of the computational and informational aspects of genomics and proteomics. Includes aspects of sequence similarity analysis, sequence similarity searches, pair-wise analysis, phylogenic trees (and relevance to human genomics), allelic variation analysis, user interface in health care management, population genetics, genomics data results analysis, data quality, and predictions and confirmations of genomics-based altered drug responses.
PGX 533 Data Analysis/Biostatistcs - 3 hours
Discusses the use of statistical methods to process public health and genetic data. An emphasis on interpretation and concepts in areas such as population genetics, genome-wide association studies and systems biology will be undertaken.
PGX 534 Analytical Technology III - 2 hours
(Laboratory) A continuation of analytical techniques related to DNA collection, preparation, analysis, here, focusing on DNA data storage, retrieval, interpretation, and reporting.
PGX 536 Applied Pharmacogenomics II - 3 hours
A continuation of Applied Pharmacogenomics and will continue to focus on single nucleotide polymorphisms and other genetic variation and their potential impact on clinical medicine and related clinical outcomes. The translation of genetic variations to drug selection, dosing regimens, adverse effects, and regimen optimization will be discussed.
PGX 539 Patient Genome Evaluation III - 2 hours
(Laboratory) Overarching project involving concepts from each course applied to an individual’s genetic information.