Required Coursework:
PGX 501 Introduction to Pharmacogenomics 2 credits
Prerequisite: none
A presentation of the evolution of pharmacogenetics/pharmacogenomics, the human genome and modern applications of DNA information related to drugs. There will also be focused attention to necessary calculations for research and an introduction to pharmacokinetics.
PGX 515 Research Responsibility and Ethics 1 credit
Prerequisite: none
Discusses ethics of scientific research involving humans. Bioethics and how it is applied to design and conduct of human drug research. Ethical issues involved with personal genetic information will be emphasized.
PGX 505 Pharmacology 4 credits
Prerequisite: none
Discusses the cellular and molecular mechanisms of drug action, studied within the disciplines of neuropharmacology and cardiovascular pharmacology, endocrine pharmacology, antimicrobials, and cancer pharmacology. Included are lectures on basic physiology that underlie the mechanisms of important pharmacological agents. Special topics include drug discovery, new uses for established drugs, and pharmacogenetic/pharmacogenomic effects.
PGX 521 Human Genetics 4 credits
Prerequisite: none
Discusses how genes influence human traits, diseases, and behaviors, including how non-genetic factors interact with genetic factors to produce observable phenotypes. Human inheritance patterns, genome organization, linkage, and medical applications of genetics in the diagnosis, treatment, and prevention of disease will be explored. There will also be an introduction to molecular biology.
PGX 526 Applied Pharmacogenomics I 3 credits
Prerequisite: PGX 501 (grade of “C” or better or permission)
Discusses single nucleotide polymorphisms and other genetic variations and their potential impact on clinical medicine and related clinical outcomes. The translation of genetic variations to drug selection, dosing regimens, adverse effects, and regimen optimization will be discussed.
PGX 531 Bioinformatics 4 credits
Prerequisite: none
Introduction and exploration of the computational and informational aspects of genomics and proteomics. Includes aspects of sequence similarity analysis, sequence similarity searches, pair-wise analysis, phylogenic trees (and relevance to human genomics), allelic variation analysis, user interface in health care management, population genetics, genomics data results analysis, data quality, and predictions and confirmations of genomics-based altered drug responses.
PGX 512 Advanced Pharmacokinetics 2 credits
Prerequisite: PGX 501 (grade of “C” or better or permission)
Discusses the mathematical and conceptual study of the time course of drug absorption, distribution, metabolism, and excretion.
PGX 536 Applied Pharmacogenomics II 3 credits
Prerequisites: PGX 501 and PGX 526 (grade of “C” or better or permission)
A continuation of Applied Pharmacogenomics and will continue to focus on single nucleotide polymorphisms and other genetic variation and their potential impact on clinical medicine and related clinical outcomes. The translation of genetic variations to drug selection, dosing regimens, adverse effects, and regimen optimization will be discussed.
PGX 511 Advanced Molecular Biology 3 credits
Prerequisite: PGX 521 (grade of “C” or better or permission)
Concepts will be related to analytical methodology. Current approaches to DNA manipulation and mutation analysis, protein assays, quantitative analysis of gene expression, sequencing, immunostaining, microscopy, and image analysis will be discussed.
PGX 533 Data Analysis/Biostatistics 3 credits
Prerequisite: none
Discusses the use of statistical methods to process public health and genetic data. An emphasis on interpretation and concepts in areas such as population genetics, genome-wide association studies and systems biology will be undertaken.
Elective Course work:
PGX 514 Analytical Technology I 1 credit
Prerequisite: none
On-Campus: Analytical technique approaches in molecular biology, such as DNA, manipulation and mutation analysis, protein assays, and quantitative analysis of gene expression, among other techniques.
PGX 524 Analytical Technology II 2 credits
Prerequisite: PGX 514 (grade of “C” or better or permission)
On-Campus: Continuation of Analytical Technology I
PGX 534 Analytical Technology III 2 credits
Prerequisites: PGX 514 and PGX 524 (grade of “C” or better or permission)
On-Campus: Continuation of Analytical Technology I
PGX 508 Pharmacogenomics in Practice I 3 credits
Prerequisites: PGX 501 (grade of “C” or better or permission)
Online: A two-part course focused in application of pharmacogenomics in a practice setting. The course will include practicums, write-ups and discussions of complicated patient cases. The course will also include the composition of a business plan or implementation plan for introducing pharmacogenomics into the practice of a practicum site.
PGX 528 Pharmacogenomics in Practice II 2 credits
Prerequisites: PGX 501 and PGX 508 (grade of “C” or better or permission)
Online: Continuation of Pharmacogenomics in Practice I
PGX 462 Research and Innovative Practice Seminar 1 credit
Prerequisite: none
On-Campus or Online: Current topics, innovative practice, and current research in pharmacy, pharmaceutical sciences, and related scientific disciplines will be presented. Invited speakers from within and outside the Manchester community will provide a formal seminar, exposing students to research methodologies, potential student research projects, and networking opportunities. Online students will participate by watching recorded seminars on their own time.
PGX 592 Pharmacogenomics Lab 1 credit
Prerequisite: none
Special notes: This course includes an additional laboratory fee. Only domestic students are eligible to enroll.
On-Campus: This on campus laboratory course introduces modern analytical techniques commonly used for DNA, RNA, and protein collection, isolation, preparation, and analysis. Students will have the opportunity to actively engage in laboratory processes associated with pharmacogenomics. The course is one-week in length and students will work for 40 hours that week.